Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot studySARS-COV-2 감염 및 급성 신장 손상 마커에 의해 유도 된 변경된 신장 기능 COVID-19 환자의 생존 결과를 예측합니다 : 전향 적 파일럿 연구Article Published on 2022-12-012022-08-31 Journal: Renal failure [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute kidney Acute kidney injury adjusted Advancing age Altered Analysis association Biomarker chronic Chronic kidney disease collaboration Comorbidities Comorbidity Control coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 COVID-19 patient COVID-19 patients creatinine Cumulative rates cystatin C death demonstrated elevated examined group groups Hospitalized ICU intensive care intensive care unit investigated Kaplan-Meier method kidney kidney damage Kidney disease Kidney function Kidney function tests Kidney injury literature marker morbidity multivariable Cox regression outcome participant pilot study predict Predictive Predictive value Proteinuria retained risk factor Risk factors SARS-COV-2 infection serum serum creatinine Sex significant difference statistically subject survival survival analysis survival analysis. the Kaplan-Meier method Treatment Urine with COVID-19 [DOI] 10.1080/0886022X.2022.2032743 PMC 바로가기 [Article Type] Article
Clinical features and high-resolution chest computerized tomography findings of children infected by the B.1.617.2 variant of coronavirus disease 2019Article Published on 2022-12-012022-11-16 Journal: Annals of Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] absence age analysed analyses B.1.617.2 B.1.617.2 (Delta) variant biochemical Blood Cell Chest Chest CT chest. children China clinical clinical symptom Clinical symptoms collected Computerized tomography Concentration consolidation coronavirus disease corpuscular correlated correlation cough COVID-19 CT CT finding Delta Diagnosis Disease diagnosis disease stage distribution elevated Factor feature Fever Follow-up ground-glass opacity group Haemoglobin High-resolution imaging Infection Laboratory Laboratory tests lymphocyte males Mild monocyte Nanjing no difference pathological change Patient percentage pharyngeal Platelet regression analysis serum alkaline phosphatase significant effect Stage stages statistically significant Subtypes Symptom Symptoms the disease variant Volume [DOI] 10.1080/07853890.2022.2114608 PMC 바로가기
The Third dose of CoronVac vaccination induces broad and potent adaptive immune responses that recognize SARS-CoV-2 Delta and Omicron variantsCoronVac 백신 3차 접종은 SARS-CoV-2 Delta 및 Omicron 변이체를 인식하는 광범위하고 강력한 적응 면역 반응 유도Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response B cell B cells boost booster booster dose booster vaccination CD4 CD8 Cell circulating comparable contagious CoronaVac coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta demonstrated detectable domain dose effective elevated elicited fold follicular healthy subject helper T cell Humoral immunity IgA responses immune responses Inactivated vaccine individual induce memory B memory B cell memory B cells neutralization neutralization activities neutralization activity neutralization. neutralizing activities omicron Omicron variants peaked predominant preserved Protein RBD receiving recognize reduced remained respiratory response SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 variant significantly increased spike-specific IgG strain subpopulations sustained T cell T cell responses T cells T cells response vaccination variant variants VOCs [DOI] 10.1080/22221751.2022.2081614 PMC 바로가기 [Article Type] Article
A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levelsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] (Post)vaccinal immunity adaptive Analysis analyzed Anti-RBD IgG anti-SARS-CoV-2 anti-SARS-CoV-2 IgG Antibody detection Antibody titers association biochemical BNT162b2 mRNA BNT162b2 mRNA vaccine changes in Concentration Cu Effect elevated Essential Essential trace elements expressed female follow-up period glycoprotein healthy HEK-293 human serum IgG antibody Immunity immunization investigated mRNA vaccine mRNA vaccine. not affected observation period produced producing Protein purified RBD Receptor binding domain remained SARS-CoV-2 sera serum specific IgG antibody spike T cells Total Trace element vaccination Vaccine Volunteer women Zn [DOI] 10.1016/j.jtemb.2022.127079 PMC 바로가기
Saliva as a Potential Specimen to Monitor IL-6, TNF-α and IL-10 in COVID-19 PatientsArticle Published on 2022-12-012022-11-15 Journal: Inflammation [Category] COVID19(2023년), SARS, 치료기술, [키워드] alleviate Blood blood specimen Clinical prognosis collected comparable COVID-19 COVID-19 patients cycle threshold detectable elevated elicited enrolled expressed expression human saliva IL-10 IL-10. IL-6 inclusion criteria Infection Inflammation Inflammation. Inflammatory Inflammatory cytokine inflammatory gene Lung injury marker MINI Mortality Patient pilot study Potential protocols Qiagen RNA RT-PCR Saliva SARS-CoV-2 severe cases specimen subject the mean TNF-α were assessed [DOI] 10.1007/s10753-022-01698-x PMC 바로가기
Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysisReview article Published on 2022-12-012022-10-05 Journal: IJC Heart & Vasculature [Category] 바이오마커, [키워드] addition age average BNT162b2 Broken heart syndrome Cardiomyopathy Case report ChAdOx1 nCoV-19 Complication concern conducted COVID-19 COVID-19 vaccinations COVID-19 vaccine COVID-19 vaccines ECG Ejection fraction elevated female first dose Google Scholar Hospital stay individual life-threatening LVEF male Messenger RNA Meta-analysis mRNA mRNA vaccine mRNA-1273 occurred onset of symptom Pain participated Patient patients raised receiving second dose Stress Stress cardiomyopathy Symptom Symptoms systematic literature search systematic review Takotsubo cardiomyopathy TCM the mean the patient troponin test vaccination Vaccines ventricular Web of Science with COVID-19 [DOI] 10.1016/j.ijcha.2022.101108 [Article Type] Review article
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasoneArticle Published on 2022-11-052022-11-15 Journal: Respiratory Research [Category] SARS, 바이오마커, [키워드] Admission association Biomarker Biomarkers Blood level Clinical management Control correlated covariates COVID-19 COVID-19 patient COVID-19 patients death Determination Dexamethasone died disease severity elevated Follow-up greater host inflammatory response IL-6 increased risk independent Infection Inflammation investigated Mortality NEWS2 Patient patient population patients patients treated Pearson positive positive individual predict prognostic RAGE receptor reduce risk SARS-CoV-2 score second wave significantly lower sRAGE. subject Teaching treated Treatment university [DOI] 10.1186/s12931-022-02220-5 PMC 바로가기
Humoral response and safety of BNT162b2 mRNA vaccine in children with rheumatic diseasesArticle Published on 2022-11-022022-11-15 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] acute respiratory syndrome Administered Anti-RBD IgG antibody Antibody Response approval baseline biologic BNT162b2 mRNA BNT162b2 mRNA vaccine children Cohort cohort of patient Combined therapy coronavirus coronavirus disease COVID-19 disease Disease activity domain dose dose regimen effective elevated evaluated humoral Humoral response IgG antibody immunogenicity immunomodulatory IQR Local median mRNA vaccine of BNT162b2 paediatric rheumatic disease. pandemic Patient RBD receiving rheumatic disease safety profile SARS-CoV-2 second dose significantly lower Spike protein study period systemic side effect titre treated Treatment Vaccine were measured [DOI] 10.1093/rheumatology/keac140 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기